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Substitution of cysteines in the yeast viral killer toxin K1 precursor reveals novel insights in heterodimer formation and immunity

The killer toxin K1 is a virally encoded fungal A/B toxin acting by disrupting plasma membrane integrity. The connection of α and β constitutes a critical feature for toxin biology and for decades the formation of three disulphide bonds linking the major toxin subunits was accepted as status quo. Du...

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Detalles Bibliográficos
Autores principales: Gier, Stefanie, Lermen, Matthias, Schmitt, Manfred J., Breinig, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739482/
https://www.ncbi.nlm.nih.gov/pubmed/31511600
http://dx.doi.org/10.1038/s41598-019-49621-z