Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of mutant clones. Some mutations are under positive selection, conferring a competitive advantage over wild-type cells. We speculated that altering the selective pressure on mutant cell populations may cause them to...

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Detalles Bibliográficos
Autores principales: Fernandez-Antoran, David, Piedrafita, Gabriel, Murai, Kasumi, Ong, Swee Hoe, Herms, Albert, Frezza, Christian, Jones, Philip H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739485/
https://www.ncbi.nlm.nih.gov/pubmed/31327664
http://dx.doi.org/10.1016/j.stem.2019.06.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739485/
https://www.ncbi.nlm.nih.gov/pubmed/31327664
http://dx.doi.org/10.1016/j.stem.2019.06.011

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