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Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes

Ligand binding site structure has profound consequences for the evolution of function of protein complexes, particularly in homomers—complexes comprising multiple copies of the same protein. Previously, we have shown that homomers with multichain binding sites (MBSs) are characterized by more conser...

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Detalles Bibliográficos
Autores principales: Abrusán, György, Marsh, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739599/
https://www.ncbi.nlm.nih.gov/pubmed/31306664
http://dx.doi.org/10.1016/j.jmb.2019.07.014