Cyclin E Overexpression in Human Mammary Epithelial Cells Promotes Epithelial Cancer-Specific Copy Number Alterations

Cyclin E, a key cell cycle regulatory protein, has been linked to oncogenesis when dysregulated. We have previously shown that overexpression of cyclin E causes replication stress, leading to failure to complete replication at specific chromosomal loci during S phase of the cell cycle. This in turn...

Descripción completa

Detalles Bibliográficos
Autores principales: Giraldez, Servando, Tamayo, Pablo, Wineinger, Nathan, Kim, William, Reed, Steven I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739637/
https://www.ncbi.nlm.nih.gov/pubmed/31513970
http://dx.doi.org/10.1016/j.isci.2019.08.043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739637/
https://www.ncbi.nlm.nih.gov/pubmed/31513970
http://dx.doi.org/10.1016/j.isci.2019.08.043

Ejemplares similares