CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease

The mechanisms underlying the selective degeneration of medium spiny neurons (MSNs) in Huntington disease (HD) remain largely unknown. CTIP2, a transcription factor expressed by all MSNs, is implicated in HD pathogenesis because of its interactions with mutant huntingtin. Here, we report a key role...

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Detalles Bibliográficos
Autores principales: Fjodorova, Marija, Louessard, Morgane, Li, Zongze, De La Fuente, Daniel C., Dyke, Emma, Brooks, Simon P., Perrier, Anselme L., Li, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739739/
https://www.ncbi.nlm.nih.gov/pubmed/31447328
http://dx.doi.org/10.1016/j.stemcr.2019.07.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739739/
https://www.ncbi.nlm.nih.gov/pubmed/31447328
http://dx.doi.org/10.1016/j.stemcr.2019.07.015

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