Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

CRISPR-Cas systems protect bacteria and archaea from phages and other mobile genetic elements, which use small anti-CRISPR (Acr) proteins to overcome CRISPR-Cas immunity. Because Acrs are challenging to identify, their natural diversity and impact on microbial ecosystems are underappreciated. To ove...

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Detalles Bibliográficos
Autores principales: Forsberg, Kevin J, Bhatt, Ishan V, Schmidtke, Danica T, Javanmardi, Kamyab, Dillard, Kaylee E, Stoddard, Barry L, Finkelstein, Ilya J, Kaiser, Brett K, Malik, Harmit S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739867/
https://www.ncbi.nlm.nih.gov/pubmed/31502535
http://dx.doi.org/10.7554/eLife.46540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739867/
https://www.ncbi.nlm.nih.gov/pubmed/31502535
http://dx.doi.org/10.7554/eLife.46540

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