A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

Endocytosis of transmembrane proteins is orchestrated by the AP2 clathrin adaptor complex. AP2 dwells in a closed, inactive state in the cytosol, but adopts an open, active conformation on the plasma membrane. Membrane-activated complexes are also phosphorylated, but the significance of this mark is...

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Detalles Bibliográficos
Autores principales: Partlow, Edward A, Baker, Richard W, Beacham, Gwendolyn M, Chappie, Joshua S, Leschziner, Andres E, Hollopeter, Gunther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739873/
https://www.ncbi.nlm.nih.gov/pubmed/31464684
http://dx.doi.org/10.7554/eLife.50003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739873/
https://www.ncbi.nlm.nih.gov/pubmed/31464684
http://dx.doi.org/10.7554/eLife.50003

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