The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance

BACKGROUND: Robustness and evolutionary stability of gene expression in the human genome are established by an array of redundant enhancers. RESULTS: Using Hi-C data in multiple cell lines, we report a comprehensive map of promoters and active enhancers connected by chromatin contacts, spanning 9000...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Wei, Sharan, Roded, Ovcharenko, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739990/
https://www.ncbi.nlm.nih.gov/pubmed/31514731
http://dx.doi.org/10.1186/s13059-019-1808-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739990/
https://www.ncbi.nlm.nih.gov/pubmed/31514731
http://dx.doi.org/10.1186/s13059-019-1808-y

Ejemplares similares