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The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance
BACKGROUND: Robustness and evolutionary stability of gene expression in the human genome are established by an array of redundant enhancers. RESULTS: Using Hi-C data in multiple cell lines, we report a comprehensive map of promoters and active enhancers connected by chromatin contacts, spanning 9000...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739990/ https://www.ncbi.nlm.nih.gov/pubmed/31514731 http://dx.doi.org/10.1186/s13059-019-1808-y |