NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival

DNA damage signaling is critical for the maintenance of genome integrity and cell fate decision. Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor rapidly activated in a damage dose- and complexity-dependent manner playing a critical role in the initial chromatin organization and DNA repa...

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Detalles Bibliográficos
Autores principales: Murata, Michael M., Kong, Xiangduo, Moncada, Emmanuel, Chen, Yumay, Imamura, Hiromi, Wang, Ping, Berns, Michael W., Yokomori, Kyoko, Digman, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740200/
https://www.ncbi.nlm.nih.gov/pubmed/31390283
http://dx.doi.org/10.1091/mbc.E18-10-0650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740200/
https://www.ncbi.nlm.nih.gov/pubmed/31390283
http://dx.doi.org/10.1091/mbc.E18-10-0650

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