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NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival
DNA damage signaling is critical for the maintenance of genome integrity and cell fate decision. Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor rapidly activated in a damage dose- and complexity-dependent manner playing a critical role in the initial chromatin organization and DNA repa...
Autores principales: | Murata, Michael M., Kong, Xiangduo, Moncada, Emmanuel, Chen, Yumay, Imamura, Hiromi, Wang, Ping, Berns, Michael W., Yokomori, Kyoko, Digman, Michelle A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740200/ https://www.ncbi.nlm.nih.gov/pubmed/31390283 http://dx.doi.org/10.1091/mbc.E18-10-0650 |
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