Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways

Although doxorubicin (DOX)-induced cardiomyopathy causes lethal heart failure (HF), no early detection or effective treatment methods are available. The principal mechanisms of cardiotoxicity are considered to involve oxidative stress and apoptosis of cardiomyocytes. However, the effect of DOX on ca...

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Detalles Bibliográficos
Autores principales: Narikawa, Masatoshi, Umemura, Masanari, Tanaka, Ryo, Hikichi, Mayu, Nagasako, Akane, Fujita, Takayuki, Yokoyama, Utako, Ishigami, Tomoaki, Kimura, Kazuo, Tamura, Kouichi, Ishikawa, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742217/
https://www.ncbi.nlm.nih.gov/pubmed/31513610
http://dx.doi.org/10.1371/journal.pone.0221940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742217/
https://www.ncbi.nlm.nih.gov/pubmed/31513610
http://dx.doi.org/10.1371/journal.pone.0221940

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