Cargando…

Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways

Although doxorubicin (DOX)-induced cardiomyopathy causes lethal heart failure (HF), no early detection or effective treatment methods are available. The principal mechanisms of cardiotoxicity are considered to involve oxidative stress and apoptosis of cardiomyocytes. However, the effect of DOX on ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Narikawa, Masatoshi, Umemura, Masanari, Tanaka, Ryo, Hikichi, Mayu, Nagasako, Akane, Fujita, Takayuki, Yokoyama, Utako, Ishigami, Tomoaki, Kimura, Kazuo, Tamura, Kouichi, Ishikawa, Yoshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742217/ https://www.ncbi.nlm.nih.gov/pubmed/31513610 http://dx.doi.org/10.1371/journal.pone.0221940

Ejemplares similares

Reactive fibrosis precedes doxorubicin‐induced heart failure through sterile inflammation
por: Tanaka, Ryo, et al.
Publicado: (2020)

Hydrostatic pressure suppresses fibrotic changes via Akt/GSK‐3 signaling in human cardiac fibroblasts
por: Tanaka, Ryo, et al.
Publicado: (2018)

Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling
por: Narikawa, Masatoshi, et al.
Publicado: (2018)

Alternating magnetic field enhances cytotoxicity of Compound C
por: Akimoto, Taisuke, et al.
Publicado: (2018)

Prostaglandin E(2) receptor EP4 regulates cell migration through Orai1
por: Osawa, Kohei, et al.
Publicado: (2019)

Simultaneous hyperthermia‐chemotherapy effect by arterial injection of Fe(Salen) for femur tumor
por: Umemura, Masanari, et al.
Publicado: (2018)

Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts
por: Nemoto, Hiroko, et al.
Publicado: (2022)

Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism
por: Cai, Wenqian, et al.
Publicado: (2019)

Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice
por: Suita, Kenji, et al.
Publicado: (2015)

Arterial graft with elastic layer structure grown from cells
por: Yokoyama, Utako, et al.
Publicado: (2017)

Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment
por: Ohtake, Makoto, et al.
Publicado: (2017)

Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus
por: Saito, Junichi, et al.
Publicado: (2018)

A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm
por: Mamun, Al, et al.
Publicado: (2018)

Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus
por: Ito, Satoko, et al.
Publicado: (2020)

Store-Operated Ca(2) (+) Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration
por: Umemura, Masanari, et al.
Publicado: (2014)

Epac activation inhibits IL-6-induced cardiac myocyte dysfunction
por: Jin, Huiling, et al.
Publicado: (2016)

Correction to: Epac activation inhibits IL-6-induced cardiac myocyte dysfunction
por: Jin, Huiling, et al.
Publicado: (2019)

Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation
por: Hiromi, Taro, et al.
Publicado: (2020)

Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles
por: Sato, Itaru, et al.
Publicado: (2016)

An interesting link between quality of sleep and a measure of blood pressure variability
por: Tamura, Kouichi, et al.
Publicado: (2020)

Role of Tissue-Type Plasminogen Activator in Remodeling of the Ductus Arteriosus
por: Saito, Junichi, et al.
Publicado: (2020)

Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats
por: Nakamura, Takashi, et al.
Publicado: (2021)

Increased Plasma Levels of Myosin Heavy Chain 11 Is Associated with Atherosclerosis
por: Takahashi, Lisa, et al.
Publicado: (2021)

Challenges and Possibilities of Cell-Based Tissue-Engineered Vascular Grafts
por: Saito, Junichi, et al.
Publicado: (2021)

Treatment of oral cancer using magnetized paclitaxel
por: Nakakaji, Rina, et al.
Publicado: (2018)

Gut microbiota and atherosclerosis: role of B cell for atherosclerosis focusing on the gut-immune-B2 cell axis
por: Chen, Lin, et al.
Publicado: (2020)

The Types and Proportions of Commensal Microbiota Have a Predictive Value in Coronary Heart Disease
por: Chen, Lin, et al.
Publicado: (2021)

Protection of Cardiomyocytes from the Hypoxia-Mediated Injury by a Peptide Targeting the Activator of G-Protein Signaling 8
por: Sato, Motohiko, et al.
Publicado: (2014)

Regulators of Epithelial Sodium Channels in Aldosterone-Sensitive Distal Nephrons (ASDN): Critical Roles of Nedd4L/Nedd4-2 and Salt-Sensitive Hypertension
por: Ishigami, Tomoaki, et al.
Publicado: (2020)

Optimal Anticoagulant Strategy for Periprocedural Management of Atrial Fibrillation Ablation: A Systematic Review and Network Meta-Analysis
por: Kino, Tabito, et al.
Publicado: (2022)

A case report of pulmonary vein isolation with radiofrequency catheter using superior vena cava approach in patient with paroxysmal atrial fibrillation and inferior vena cava filter
por: Narikawa, Masatoshi, et al.
Publicado: (2021)

Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II‐infused mice
por: Wakui, Hiromichi, et al.
Publicado: (2017)

Native T1 time and extracellular volume fraction in differentiation of normal myocardium from non-ischemic dilated and hypertrophic cardiomyopathy myocardium: A systematic review and meta-analysis
por: Minegishi, Shintaro, et al.
Publicado: (2019)

Direct Oral Anticoagulant Therapy for Isolated Distal Deep Vein Thrombosis Associated with Cancer in Routine Clinical Practice
por: Ogino, Yutaka, et al.
Publicado: (2021)

Quantitative Assessment of Tissue Perfusion in Hepatocellular Carcinoma Using Perflubutane Dynamic Contrast-Enhanced Ultrasonography: A Preliminary Study
por: Ohno, Naoki, et al.
Publicado: (2015)

Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca(2+)-dependent manner
por: Fujita, Takayuki, et al.
Publicado: (2006)

Lubiprostone as a potential therapeutic agent to improve intestinal permeability and prevent the development of atherosclerosis in apolipoprotein E-deficient mice
por: Arakawa, Kentaro, et al.
Publicado: (2019)

An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice
por: Minegishi, Shintaro, et al.
Publicado: (2016)

Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3
por: Tsutsumi, Yasuo M, et al.
Publicado: (2014)

The Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Japanese Volunteers
por: Umemura, Kazuo, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nuivnn7229uu1d60r06pcqbtb7