False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases

BACKGROUND: More than 11,000 laboratories and companies developed their own next-generation sequencing (NGS) for screening and diagnosis of various diseases including cancer. Although inconsistencies of mutation calls as high as 43% in databases such as GDSC (Genomics of Drug Sensitivity in Cancer)...

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Detalles Bibliográficos
Autores principales: Kim, Young-Ho, Song, Yura, Kim, Jong-Kwang, Kim, Tae-Min, Sim, Hye Won, Kim, Hyung-Lae, Jang, Hyonchol, Kim, Young-Woo, Hong, Kyeong-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742382/
https://www.ncbi.nlm.nih.gov/pubmed/31513681
http://dx.doi.org/10.1371/journal.pone.0222535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742382/
https://www.ncbi.nlm.nih.gov/pubmed/31513681
http://dx.doi.org/10.1371/journal.pone.0222535

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