Design, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-β probes

To develop novel CNS penetrant HDAC inhibitors, a new series of HDAC inhibitors having benzoheterocycle were designed, synthesized, and biologically evaluated. Among the synthesized compounds, benzothiazole derivative 9b exhibited a remarkable anti-proliferative activity (GI(50) = 2.01 μM) against S...

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Detalles Bibliográficos
Autores principales: Choi, Myeong A, Park, Sun You, Chae, Hye Yun, Song, Yoojin, Sharma, Chiranjeev, Seo, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742641/
https://www.ncbi.nlm.nih.gov/pubmed/31515509
http://dx.doi.org/10.1038/s41598-019-49784-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742641/
https://www.ncbi.nlm.nih.gov/pubmed/31515509
http://dx.doi.org/10.1038/s41598-019-49784-9

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