Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Each human genome carries tens of thousands of coding variants. The extent to which this variation is functional and the mechanisms by which they exert their influence remains largely unexplored. To address this gap, we leverage the ExAC database of 60,706 human exomes to investigate experimentally...

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Detalles Bibliográficos
Autores principales: Fragoza, Robert, Das, Jishnu, Wierbowski, Shayne D., Liang, Jin, Tran, Tina N., Liang, Siqi, Beltran, Juan F., Rivera-Erick, Christen A., Ye, Kaixiong, Wang, Ting-Yi, Yao, Li, Mort, Matthew, Stenson, Peter D., Cooper, David N., Wei, Xiaomu, Keinan, Alon, Schimenti, John C., Clark, Andrew G., Yu, Haiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742646/
https://www.ncbi.nlm.nih.gov/pubmed/31515488
http://dx.doi.org/10.1038/s41467-019-11959-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742646/
https://www.ncbi.nlm.nih.gov/pubmed/31515488
http://dx.doi.org/10.1038/s41467-019-11959-3

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