Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p

The heterodimeric eukaryotic Drs2p-Cdc50p complex is a lipid flippase that maintains cell membrane asymmetry. The enzyme complex exists in an autoinhibited form in the absence of an activator and is specifically activated by phosphatidylinositol-4-phosphate (PI4P), although the underlying mechanisms...

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Detalles Bibliográficos
Autores principales: Bai, Lin, Kovach, Amanda, You, Qinglong, Hsu, Hao-Chi, Zhao, Gongpu, Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742660/
https://www.ncbi.nlm.nih.gov/pubmed/31515475
http://dx.doi.org/10.1038/s41467-019-12191-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742660/
https://www.ncbi.nlm.nih.gov/pubmed/31515475
http://dx.doi.org/10.1038/s41467-019-12191-9

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