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Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
The heterodimeric eukaryotic Drs2p-Cdc50p complex is a lipid flippase that maintains cell membrane asymmetry. The enzyme complex exists in an autoinhibited form in the absence of an activator and is specifically activated by phosphatidylinositol-4-phosphate (PI4P), although the underlying mechanisms...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742660/ https://www.ncbi.nlm.nih.gov/pubmed/31515475 http://dx.doi.org/10.1038/s41467-019-12191-9 |