Influence of Rifampin‐Mediated Organic Anion‐Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan

Clazosentan is a selective endothelin A receptor antagonist in development for the prevention and treatment of vasospasm postsubarachnoid hemorrhage. It is a substrate of organic anion‐transporting polypeptide 1B1/1B3 based on preclinical data. This randomized, double‐blind, two‐period, cross‐over s...

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Detalles Bibliográficos
Autores principales: Juif, Pierre‐Eric, Voors‐Pette, Christine, Ufer, Mike, Dogterom, Peter, Dingemanse, Jasper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742933/
https://www.ncbi.nlm.nih.gov/pubmed/31004470
http://dx.doi.org/10.1111/cts.12639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742933/
https://www.ncbi.nlm.nih.gov/pubmed/31004470
http://dx.doi.org/10.1111/cts.12639

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