“Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a review

Hirschsprung disease is a neurocristopathy, characterized by aganglionosis in the distal bowel. It is caused by failure of the enteric nervous system progenitors to migrate, proliferate, and differentiate in the gut. Development of an enteric nervous system is a tightly regulated process. Both the n...

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Detalles Bibliográficos
Autores principales: Jaroy, Emilie G., Acosta-Jimenez, Lourdes, Hotta, Ryo, Goldstein, Allan M., Emblem, Ragnhild, Klungland, Arne, Ougland, Rune
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743154/
https://www.ncbi.nlm.nih.gov/pubmed/31519213
http://dx.doi.org/10.1186/s13148-019-0718-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743154/
https://www.ncbi.nlm.nih.gov/pubmed/31519213
http://dx.doi.org/10.1186/s13148-019-0718-x

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