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“Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a review
Hirschsprung disease is a neurocristopathy, characterized by aganglionosis in the distal bowel. It is caused by failure of the enteric nervous system progenitors to migrate, proliferate, and differentiate in the gut. Development of an enteric nervous system is a tightly regulated process. Both the n...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743154/ https://www.ncbi.nlm.nih.gov/pubmed/31519213 http://dx.doi.org/10.1186/s13148-019-0718-x |