An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer

Epithelial-to-mesenchymal transition (EMT) is a key process in EGFR-TKI resistance but the detailed mechanism is largely unknown. We aim to evaluate the role of interleukin-6 (IL-6) and insulin-like growth factor-1 receptor (IGR-1R) in EMT in non-small cell lung cancer (NSCLC). We used IL-6 to induc...

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Detalles Bibliográficos
Autores principales: Zheng, Xianan, Lu, Guohua, Yao, Yinan, Gu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743301/
https://www.ncbi.nlm.nih.gov/pubmed/31523190
http://dx.doi.org/10.7150/ijbs.31999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743301/
https://www.ncbi.nlm.nih.gov/pubmed/31523190
http://dx.doi.org/10.7150/ijbs.31999

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