Neurons Induced From Fibroblasts of c9ALS/FTD Patients Reproduce the Pathology Seen in the Central Nervous System

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are incurable neurodegenerative conditions. A non-coding hexanucleotide (GGGGCC) repeat expansion in the c9orf72 gene is the most common genetic cause of ALS/FTD. We present a cellular model of c9ALS/FTD where induced neurons (iNe...

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Detalles Bibliográficos
Autores principales: Bauer, Peter O., Dunmore, Judith H., Sasaguri, Hiroki, Matoska, Vaclav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743368/
https://www.ncbi.nlm.nih.gov/pubmed/31551693
http://dx.doi.org/10.3389/fnins.2019.00935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743368/
https://www.ncbi.nlm.nih.gov/pubmed/31551693
http://dx.doi.org/10.3389/fnins.2019.00935

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