Overexpression of Biglycan is Associated with Resistance to Rapamycin in Human WERI-Rb-1 Retinoblastoma Cells by Inducing the Activation of the Phosphatidylinositol 3-Kinases (PI3K)/Akt/Nuclear Factor kappa B (NF-κB) Signaling Pathway

BACKGROUND: Biglycan (BGN) is an extracellular matrix (ECM) protein that regulates the growth of epithelial cells. The mammalian target of rapamycin (mTOR) inhibitor, rapamycin, is a treatment for advanced retinoblastoma. This study aimed to investigate the effects of expression of BGN on the respon...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Dong, Lai, Zhaoguang, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743380/
https://www.ncbi.nlm.nih.gov/pubmed/31483776
http://dx.doi.org/10.12659/MSM.915075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743380/
https://www.ncbi.nlm.nih.gov/pubmed/31483776
http://dx.doi.org/10.12659/MSM.915075

Ejemplares similares