Polarization and sprouting of endothelial cells by angiopoietin-1 require PAK2 and paxillin-dependent Cdc42 activation

Binding of angiopoietin-1 (Ang-1) to its receptor Tie2 on endothelial cells (ECs) promotes vessel barrier integrity and angiogenesis. Here, we identify PAK2 and paxillin as critical targets of Ang-1 responsible for EC migration, polarization, and sprouting. We found that Ang-1 increases PAK2-depende...

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Detalles Bibliográficos
Autores principales: Boscher, Cécile, Gaonac’h-Lovejoy, Vanda, Delisle, Chantal, Gratton, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743454/
https://www.ncbi.nlm.nih.gov/pubmed/31141452
http://dx.doi.org/10.1091/mbc.E18-08-0486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743454/
https://www.ncbi.nlm.nih.gov/pubmed/31141452
http://dx.doi.org/10.1091/mbc.E18-08-0486

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