Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ

Syk/Zap70 family kinases are essential for signaling via multichain immune-recognition receptors such as tetrameric (αβγ2) FcεRI. Syk activation is generally attributed to cis binding of its tandem SH2 domains to dual phosphotyrosines within FcεRIγ-ITAMs (immunoreceptor tyrosine-based activation mot...

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Detalles Bibliográficos
Autores principales: Travers, Timothy, Kanagy, William K., Mansbach, Rachael A., Jhamba, Elton, Cleyrat, Cedric, Goldstein, Byron, Lidke, Diane S., Wilson, Bridget S., Gnanakaran, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743456/
https://www.ncbi.nlm.nih.gov/pubmed/31216232
http://dx.doi.org/10.1091/mbc.E18-11-0722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743456/
https://www.ncbi.nlm.nih.gov/pubmed/31216232
http://dx.doi.org/10.1091/mbc.E18-11-0722

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