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An actin-based protrusion originating from a podosome-enriched region initiates macrophage fusion
Macrophage fusion resulting in the formation of multinucleated giant cells occurs in a variety of chronic inflammatory diseases, yet the mechanism responsible for initiating this process is unknown. Here, we used live cell imaging to show that actin-based protrusions at the leading edge initiate mac...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743464/ https://www.ncbi.nlm.nih.gov/pubmed/31242090 http://dx.doi.org/10.1091/mbc.E19-01-0009 |