Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy

The RAS-RAF-MEK-ERK signaling pathway (MAPK signaling pathway) plays a significant role in multiple pathological behaviors and is most frequently dysregulated in more than 30% of human cancers. As key elements in this pathway, MEK1/2 play crucial roles in tumorigenesis and the inhibition of apoptosi...

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Detalles Bibliográficos
Autores principales: Li, Yanan, Dong, Qingrong, Cui, Yukun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743629/
https://www.ncbi.nlm.nih.gov/pubmed/31565475
http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743629/
https://www.ncbi.nlm.nih.gov/pubmed/31565475
http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0137

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