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Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy
The RAS-RAF-MEK-ERK signaling pathway (MAPK signaling pathway) plays a significant role in multiple pathological behaviors and is most frequently dysregulated in more than 30% of human cancers. As key elements in this pathway, MEK1/2 play crucial roles in tumorigenesis and the inhibition of apoptosi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Chinese Anti-Cancer Association
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743629/ https://www.ncbi.nlm.nih.gov/pubmed/31565475 http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0137 |