Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage

Previously we have described the V2-directed CAP256-VRC26 lineage that includes broadly neutralizing antibodies (bNAbs) that neutralize globally diverse strains of HIV. We also identified highly mutated “off-track” lineage members that share high sequence identity to broad members but lack breadth....

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Detalles Bibliográficos
Autores principales: Sacks, David, Bhiman, Jinal N., Wiehe, Kevin, Gorman, Jason, Kwong, Peter D., Morris, Lynn, Moore, Penny L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743783/
https://www.ncbi.nlm.nih.gov/pubmed/31479499
http://dx.doi.org/10.1371/journal.ppat.1008005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743783/
https://www.ncbi.nlm.nih.gov/pubmed/31479499
http://dx.doi.org/10.1371/journal.ppat.1008005

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