Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low nuclear levels of Cln3, a key G1 cyclin extremely sensitive to chaperone status. Chaperone availabi...

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Detalles Bibliográficos
Autores principales: Moreno, David F, Jenkins, Kirsten, Morlot, Sandrine, Charvin, Gilles, Csikasz-Nagy, Attila, Aldea, Martí
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744273/
https://www.ncbi.nlm.nih.gov/pubmed/31518229
http://dx.doi.org/10.7554/eLife.48240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744273/
https://www.ncbi.nlm.nih.gov/pubmed/31518229
http://dx.doi.org/10.7554/eLife.48240

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