Cargando…

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription. A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II nucleosome crossing dynamics, is still missing....

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zhijie, Gabizon, Ronen, Brown, Aidan I, Lee, Antony, Song, Aixin, Díaz-Celis, César, Kaplan, Craig D, Koslover, Elena F, Yao, Tingting, Bustamante, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744274/ https://www.ncbi.nlm.nih.gov/pubmed/31364986 http://dx.doi.org/10.7554/eLife.48281

Ejemplares similares

Decoding the centromeric nucleosome through CENP-N
por: Pentakota, Satyakrishna, et al.
Publicado: (2017)

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement
por: Patel, Avinash B, et al.
Publicado: (2019)

New tools for automated high-resolution cryo-EM structure determination in RELION-3
por: Zivanov, Jasenko, et al.
Publicado: (2018)

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader
por: Gaubitz, Christl, et al.
Publicado: (2022)

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism
por: Pospich, Sabrina, et al.
Publicado: (2021)

High-resolution structures with bound Mn(2+) and Cd(2+) map the metal import pathway in an Nramp transporter
por: Ray, Shamayeeta, et al.
Publicado: (2023)

Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design
por: Hsieh, Ching-Lin, et al.
Publicado: (2017)

High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms
por: Arragain, Benoît, et al.
Publicado: (2019)

Histone Chaperone FACT Coordinates Nucleosome Interaction through Multiple Synergistic Binding Events
por: Winkler, Duane D., et al.
Publicado: (2011)

Visualization and functional dissection of coaxial paired SpoIIIE channels across the sporulation septum
por: Shin, Jae Yen, et al.
Publicado: (2015)

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes
por: Sundaramoorthy, Ramasubramanian, et al.
Publicado: (2017)

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation
por: Shang, Zhiguo, et al.
Publicado: (2014)

A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans
por: Doroquez, David B, et al.
Publicado: (2014)

Structure of the bacterial ribosome at 2 Å resolution
por: Watson, Zoe L, et al.
Publicado: (2020)

Deciphering a hexameric protein complex with Angstrom optical resolution
por: Mazal, Hisham, et al.
Publicado: (2022)

Molecular basis for N-terminal alpha-synuclein acetylation by human NatB
por: Deng, Sunbin, et al.
Publicado: (2020)

Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes
por: Lee, Sang Hak, et al.
Publicado: (2017)

Correction: Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes
por: Lee, Sang Hak, et al.
Publicado: (2017)

All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits
por: Hadden, Jodi A, et al.
Publicado: (2018)

Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution
por: Díaz-Santín, Luis Miguel, et al.
Publicado: (2017)

Top-down machine learning approach for high-throughput single-molecule analysis
por: White, David S, et al.
Publicado: (2020)

Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity
por: Lin, Zhijie, et al.
Publicado: (2019)

Computational design of peptides to target Na(V)1.7 channel with high potency and selectivity for the treatment of pain
por: Nguyen, Phuong T, et al.
Publicado: (2022)

Pore mutation N617D in the skeletal muscle DHPR blocks Ca(2+) influx due to atypical high-affinity Ca(2+) binding
por: Dayal, Anamika, et al.
Publicado: (2021)

An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases
por: Boucher, Jeffrey I, et al.
Publicado: (2014)

Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly
por: Lu, Meng, et al.
Publicado: (2019)

Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus
por: Teng, Bochuan, et al.
Publicado: (2023)

The structure of plant photosystem I super-complex at 2.8 Å resolution
por: Mazor, Yuval, et al.
Publicado: (2015)

Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization
por: Sun, Siyang, et al.
Publicado: (2013)

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles
por: Bai, Xiao-chen, et al.
Publicado: (2013)

A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging
por: Sofroniew, Nicholas James, et al.
Publicado: (2016)

Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca(2+)-dependent Cl(-) currents in human RPE
por: Li, Yao, et al.
Publicado: (2017)

Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations
por: Zhao, Qingqing, et al.
Publicado: (2021)

Drosophila melanogaster Myosin-18 Represents a Highly Divergent Motor with Actin Tethering Properties
por: Guzik-Lendrum, Stephanie, et al.
Publicado: (2011)

Two-subunit DNA escort mechanism and inactive subunit bypass in an ultra-fast ring ATPase
por: Liu, Ninning, et al.
Publicado: (2015)

High temperature sensitivity is intrinsic to voltage-gated potassium channels
por: Yang, Fan, et al.
Publicado: (2014)

2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy
por: Campbell, Melody G, et al.
Publicado: (2015)

Single-molecule imaging analysis reveals the mechanism of a high-catalytic-activity mutant of chitinase A from Serratia marcescens
por: Visootsat, Akasit, et al.
Publicado: (2020)

Monochromatic multicomponent fluorescence sedimentation velocity for the study of high-affinity protein interactions
por: Zhao, Huaying, et al.
Publicado: (2016)

The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere
por: Fisher, Gemma LM, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_siu37hn8rf2crcnbsbfbs5vnl2