Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding

Drug binding to plasma proteins is routinely determined during drug development. Albumin polymorphisms c.1075G>T (p.Ala359Ser) and c.1422A>T (p.Glu474Asp) were previously shown to alter plasma protein binding of a drug candidate (D01-4582, 4-[1-[3-chloro-4-[N′-(2-methylphenyl)ureido]phenylacet...

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Detalles Bibliográficos
Autores principales: Costa, Ana P., Court, Michael H., Burke, Neal S., Zhu, Zhaohui, Mealey, Katrina L., Villarino, Nicolas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744390/
https://www.ncbi.nlm.nih.gov/pubmed/31481400
http://dx.doi.org/10.1124/dmd.119.087304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744390/
https://www.ncbi.nlm.nih.gov/pubmed/31481400
http://dx.doi.org/10.1124/dmd.119.087304

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