Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

The ubiquitination status of RIPK1 is considered to be critical for cell fate determination. However, the in vivo role for RIPK1 ubiquitination remains undefined. Here we show that mice expressing RIPK1(K376R) which is defective in RIPK1 ubiquitination die during embryogenesis. This lethality is ful...

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Detalles Bibliográficos
Autores principales: Zhang, Xixi, Zhang, Haiwei, Xu, Chengxian, Li, Xiaoming, Li, Ming, Wu, Xiaoxia, Pu, Wenjuan, Zhou, Bin, Wang, Haikun, Li, Dali, Ding, Qiurong, Ying, Hao, Wang, Hui, Zhang, Haibing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744433/
https://www.ncbi.nlm.nih.gov/pubmed/31519886
http://dx.doi.org/10.1038/s41467-019-11839-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744433/
https://www.ncbi.nlm.nih.gov/pubmed/31519886
http://dx.doi.org/10.1038/s41467-019-11839-w

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