K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of cell death through its kinase activity. However, how its kinase activity is regulated remains poorly understood. Here, we generate Ripk1(K376R/K376R) knock-in mice in which the Lys(K)63-linked ubiquitination of RIPK1 is impaire...

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Detalles Bibliográficos
Autores principales: Tang, Yong, Tu, Hailin, Zhang, Jie, Zhao, Xueqiang, Wang, Yini, Qin, Jun, Lin, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744441/
https://www.ncbi.nlm.nih.gov/pubmed/31519887
http://dx.doi.org/10.1038/s41467-019-12033-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744441/
https://www.ncbi.nlm.nih.gov/pubmed/31519887
http://dx.doi.org/10.1038/s41467-019-12033-8

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