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K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of cell death through its kinase activity. However, how its kinase activity is regulated remains poorly understood. Here, we generate Ripk1(K376R/K376R) knock-in mice in which the Lys(K)63-linked ubiquitination of RIPK1 is impaire...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744441/ https://www.ncbi.nlm.nih.gov/pubmed/31519887 http://dx.doi.org/10.1038/s41467-019-12033-8 |