Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome homeostasis. Here we show that autophagy preserve...

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Detalles Bibliográficos
Autores principales: Holdgaard, Søs Grønbæk, Cianfanelli, Valentina, Pupo, Emanuela, Lambrughi, Matteo, Lubas, Michal, Nielsen, Julie C., Eibes, Susana, Maiani, Emiliano, Harder, Lea M., Wesch, Nicole, Foged, Mads Møller, Maeda, Kenji, Nazio, Francesca, de la Ballina, Laura R., Dötsch, Volker, Brech, Andreas, Frankel, Lisa B., Jäättelä, Marja, Locatelli, Franco, Barisic, Marin, Andersen, Jens S., Bekker-Jensen, Simon, Lund, Anders H., Rogov, Vladimir V., Papaleo, Elena, Lanzetti, Letizia, De Zio, Daniela, Cecconi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744468/
https://www.ncbi.nlm.nih.gov/pubmed/31519908
http://dx.doi.org/10.1038/s41467-019-12094-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744468/
https://www.ncbi.nlm.nih.gov/pubmed/31519908
http://dx.doi.org/10.1038/s41467-019-12094-9

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