Mimicking in-vivo exposures to drug combinations in-vitro: anti-tuberculosis drugs in lung lesions and the hollow fiber model of infection

Here, we evaluate protocol requirements to mimic therapeutically relevant drug concentrations at the site of infection (i.e. lung lesion) in an in-vitro hollow fibre model of infection using pulmonary tuberculosis as a paradigm. Steady-state pharmacokinetic profiles in plasma, lung tissue and lung l...

Descripción completa

Detalles Bibliográficos
Autores principales: Kloprogge, Frank, Hammond, Robert, Kipper, Karin, Gillespie, Stephen H., Della Pasqua, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744479/
https://www.ncbi.nlm.nih.gov/pubmed/31519935
http://dx.doi.org/10.1038/s41598-019-49556-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744479/
https://www.ncbi.nlm.nih.gov/pubmed/31519935
http://dx.doi.org/10.1038/s41598-019-49556-5

Ejemplares similares