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Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

Cell migration during the invasion-metastasis cascade requires cancer cells to navigate a spatially complex microenvironment that presents directional choices to migrating cells. Here, we investigate cellular energetics during migration decision-making in confined spaces. Theoretical and experimenta...

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Detalles Bibliográficos
Autores principales: Zanotelli, Matthew R., Rahman-Zaman, Aniqua, VanderBurgh, Jacob A., Taufalele, Paul V., Jain, Aadhar, Erickson, David, Bordeleau, Francois, Reinhart-King, Cynthia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744572/
https://www.ncbi.nlm.nih.gov/pubmed/31519914
http://dx.doi.org/10.1038/s41467-019-12155-z