The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease

T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis. The differentiation of Th17 cells is dependent on the retinoic acid receptor-related orphan nuclear receptor RORγt. Here, we identify REV-ERBα (encode...

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Detalles Bibliográficos
Autores principales: Chang, Christina, Loo, Chin-San, Zhao, Xuan, Solt, Laura A., Liang, Yuqiong, Bapat, Sagar P., Cho, Han, Kamenecka, Theodore M., Leblanc, Mathias, Atkins, Annette R., Yu, Ruth T., Downes, Michael, Burris, Thomas P., Evans, Ronald M., Zheng, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744854/
https://www.ncbi.nlm.nih.gov/pubmed/31455731
http://dx.doi.org/10.1073/pnas.1907563116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744854/
https://www.ncbi.nlm.nih.gov/pubmed/31455731
http://dx.doi.org/10.1073/pnas.1907563116

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