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Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature

INTRODUCTION: Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat. The novel anticonvulsant perampanel may be effective in the treatment of status epilepticus considering its mechanism of action of being an AMPA antagonist. We present four cases of sup...

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Autores principales: Newey, Christopher R., Mullaguri, Naresh, Hantus, Stephen, Punia, Vineet, George, Pravin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745135/
https://www.ncbi.nlm.nih.gov/pubmed/31565443
http://dx.doi.org/10.1155/2019/3218231
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author Newey, Christopher R.
Mullaguri, Naresh
Hantus, Stephen
Punia, Vineet
George, Pravin
author_facet Newey, Christopher R.
Mullaguri, Naresh
Hantus, Stephen
Punia, Vineet
George, Pravin
author_sort Newey, Christopher R.
collection PubMed
description INTRODUCTION: Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat. The novel anticonvulsant perampanel may be effective in the treatment of status epilepticus considering its mechanism of action of being an AMPA antagonist. We present four cases of super refractory status epilepticus treated with high dose perampanel. METHOD: Case report. CASES: Four patients were treated with perampanel for their refractory status epilepticus. One patient had new onset refractory status epilepticus of unknown etiology. Three other patients had status epilepticus as a result of their cardiac arrest. Two of the cardiac arrest patients had myoclonus. In all patients, the additional of perampanel resulted in a reduction of seizure burden without affecting hemodynamics or hepatic or renal function. CONCLUSION: Perampanel may be effective in the treatment of super-refractory status epilepticus of varying etiologies. A larger, prospective study is needed to further assess this therapy.
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spelling pubmed-67451352019-09-29 Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature Newey, Christopher R. Mullaguri, Naresh Hantus, Stephen Punia, Vineet George, Pravin Case Rep Crit Care Case Report INTRODUCTION: Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat. The novel anticonvulsant perampanel may be effective in the treatment of status epilepticus considering its mechanism of action of being an AMPA antagonist. We present four cases of super refractory status epilepticus treated with high dose perampanel. METHOD: Case report. CASES: Four patients were treated with perampanel for their refractory status epilepticus. One patient had new onset refractory status epilepticus of unknown etiology. Three other patients had status epilepticus as a result of their cardiac arrest. Two of the cardiac arrest patients had myoclonus. In all patients, the additional of perampanel resulted in a reduction of seizure burden without affecting hemodynamics or hepatic or renal function. CONCLUSION: Perampanel may be effective in the treatment of super-refractory status epilepticus of varying etiologies. A larger, prospective study is needed to further assess this therapy. Hindawi 2019-09-02 /pmc/articles/PMC6745135/ /pubmed/31565443 http://dx.doi.org/10.1155/2019/3218231 Text en Copyright © 2019 Christopher R. Newey et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Newey, Christopher R.
Mullaguri, Naresh
Hantus, Stephen
Punia, Vineet
George, Pravin
Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature
title Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature
title_full Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature
title_fullStr Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature
title_full_unstemmed Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature
title_short Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature
title_sort super-refractory status epilepticus treated with high dose perampanel: case series and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745135/
https://www.ncbi.nlm.nih.gov/pubmed/31565443
http://dx.doi.org/10.1155/2019/3218231
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