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DNA double-strand break formation and repair as targets for novel antibiotic combination chemotherapy
An unrepaired DNA double-strand break (DSB) is lethal to cells. In bacteria, DSBs are usually repaired either via an error-prone pathway, which ligates the ends of the break or an accurate recombination pathway. Due to this lethality, drugs that induce persistent DSBs have been successful in bacteri...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Future Science Ltd
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745595/ https://www.ncbi.nlm.nih.gov/pubmed/31534779 http://dx.doi.org/10.2144/fsoa-2019-0034 |