Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma

BACKGROUND: Life of patients with uveal melanoma (UM) is largely threatened by liver metastasis. Little is known about the drivers of liver organotropic metastasis in UM. The elevated activity of transcription of oncogenes is presumably to drive aspects of tumors. We hypothesized that inhibition of...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Liu, Shenglan, Ye, Qianyun, Pan, Jingxuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745806/
https://www.ncbi.nlm.nih.gov/pubmed/31526394
http://dx.doi.org/10.1186/s12943-019-1070-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745806/
https://www.ncbi.nlm.nih.gov/pubmed/31526394
http://dx.doi.org/10.1186/s12943-019-1070-7

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