Dasatinib-Loaded Erythrocytes Trigger Apoptosis in Untreated Chronic Myelogenous Leukemic Cells: A Cellular Reservoir Participating in Dasatinib Efficiency

Dasatinib is an ABL1 tyrosine kinase inhibitor (TKI) with a short in vivo plasmatic half-life but with good efficiency, which is not fully understood. We investigated the possibility that circulating erythrocytes store and then provide dasatinib to target cells. In vitro coincubation of dasatinib-tr...

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Detalles Bibliográficos
Autores principales: Airiau, Kelly, Turcq, Béatrice, Bouchet, Stéphane, Laharanne, Elodie, Vial, Jean-Philippe, Etienne, Gabriel, Mahon, François-Xavier, Belloc, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745996/
https://www.ncbi.nlm.nih.gov/pubmed/31723769
http://dx.doi.org/10.1097/HS9.0000000000000041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745996/
https://www.ncbi.nlm.nih.gov/pubmed/31723769
http://dx.doi.org/10.1097/HS9.0000000000000041

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