Cargando…

TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala

TMEM16B (ANO2) is the Ca(2+)-activated chloride channel expressed in multiple brain regions, including the amygdala. Here we report that Ano2 knockout mice exhibit impaired anxiety-related behaviors and context-independent fear memory, thus implicating TMEM16B in anxiety modulation. We found that TM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ke-Xin, He, Mu, Ye, Wenlei, Simms, Jeffrey, Gill, Michael, Xiang, Xuaner, Jan, Yuh Nung, Jan, Lily Yeh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746550/ https://www.ncbi.nlm.nih.gov/pubmed/31482844 http://dx.doi.org/10.7554/eLife.47106

Ejemplares similares

Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity
por: Ye, Wenlei, et al.
Publicado: (2019)

TMEM16K is an interorganelle regulator of endosomal sorting
por: Petkovic, Maja, et al.
Publicado: (2020)

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling
por: Feng, Shengjie, et al.
Publicado: (2019)

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling
por: Feng, Shengjie, et al.
Publicado: (2019)

Cryo-EM structures of the TMEM16A calcium-activated chloride channel
por: Dang, Shangyu, et al.
Publicado: (2017)

TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures
por: Wang, Tongfei A., et al.
Publicado: (2021)

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity
por: Tien, Jason, et al.
Publicado: (2014)

TMEM16C facilitates sodium-activated potassium currents in rat primary sensory neurons and regulates pain processing
por: Huang, Fen, et al.
Publicado: (2013)

Subdued, a TMEM16 family Ca(2+)-activated Cl(−) channel in Drosophila melanogaster with an unexpected role in host defense
por: Wong, Xiu Ming, et al.
Publicado: (2013)

Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila
por: Yuan, Quan, et al.
Publicado: (2013)

Identification of a conserved drug binding pocket in TMEM16 proteins
por: Cheng, Yifan, et al.
Publicado: (2022)

Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase
por: Feng, Shengjie, et al.
Publicado: (2023)

Hypothalamic Vasopressinergic Projections Innervate Central Amygdala GABAergic Neurons: Implications for Anxiety and Stress Coping
por: Hernández, Vito S., et al.
Publicado: (2016)

Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala
por: Meis, Susanne, et al.
Publicado: (2019)

The central amygdala controls learning in the lateral amygdala
por: Yu, Kai, et al.
Publicado: (2017)

Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics
por: Jan, Lily Yeh, et al.
Publicado: (2018)

Long-Term Isolation Elicits Depression and Anxiety-Related Behaviors by Reducing Oxytocin-Induced GABAergic Transmission in Central Amygdala
por: Han, Rafael T., et al.
Publicado: (2018)

IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala
por: Bajo, Michal, et al.
Publicado: (2015)

Intrinsic Circuits in the Lateral Central Amygdala
por: Hunt, Sarah, et al.
Publicado: (2017)

Contribution of Visual and Circadian Neural Circuits to Memory for Prolonged Mating Induced by Rivals
por: Kim, Woo Jae, et al.
Publicado: (2012)

Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats
por: Jiang, Hong, et al.
Publicado: (2014)

Higher anxiety and larger amygdala volumes in carriers of a TMEM132D risk variant for panic disorder
por: Haaker, J, et al.
Publicado: (2014)

Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala
por: Nie, Zhiguo, et al.
Publicado: (2009)

Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats
por: Khom, Sophia, et al.
Publicado: (2023)

Involvement of Epigenetic Modifications of GABAergic Interneurons in Basolateral Amygdala in Anxiety-like Phenotype of Prenatally Stressed Mice
por: Zhu, Chunting, et al.
Publicado: (2018)

Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development
por: Jaszczak, Jacob S, et al.
Publicado: (2022)

Reduced GABAergic Inhibition in the Basolateral Amygdala and the Development of Anxiety-Like Behaviors after Mild Traumatic Brain Injury
por: Almeida-Suhett, Camila P., et al.
Publicado: (2014)

Type 7 Adenylyl Cyclase is Involved in the Ethanol and CRF Sensitivity of GABAergic Synapses in Mouse Central Amygdala
por: Cruz, Maureen T., et al.
Publicado: (2011)

Synaptic GABAergic transmission in the central amygdala (CeA) of rats depends on slice preparation and recording conditions
por: Avegno, Elizabeth M., et al.
Publicado: (2019)

Role of MyD88 in IL-1β and Ethanol Modulation of GABAergic Transmission in the Central Amygdala
por: Bajo, Michal, et al.
Publicado: (2019)

Development of the Olfactory Epithelium and Nasal Glands in TMEM16A(-/-) and TMEM16A(+/+) Mice
por: Maurya, Devendra Kumar, et al.
Publicado: (2015)

Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae
por: Zhang, Wei, et al.
Publicado: (2014)

Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala
por: Wang, Guang-Yan, et al.
Publicado: (2016)

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy
por: Sun, Ying, et al.
Publicado: (2019)

The role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration
por: Jacobsen, K. S., et al.
Publicado: (2013)

The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling
por: O’Brien, Caitlin E., et al.
Publicado: (2022)

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala
por: Tunstall, Brendan J., et al.
Publicado: (2019)

Cellular functions of TMEM16/anoctamin
por: Oh, Uhtaek, et al.
Publicado: (2016)

Contrasting effects of phosphatidylinositol 4,5‐bisphosphate on cloned TMEM16A and TMEM16B channels
por: Ta, Chau M, et al.
Publicado: (2017)

Gating the pore of the calcium-activated chloride channel TMEM16A
por: Lam, Andy K. M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_39jg58tpholjqi0b5j91ktf5n2