Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

A major constraint for developing new anti-tuberculosis drugs is the limited number of validated targets that allow eradication of persistent infections. Here, we uncover a vulnerable component of Mycobacterium tuberculosis (Mtb) persistence metabolism, the aspartate pathway. Rapid death of threonin...

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Detalles Bibliográficos
Autores principales: Hasenoehrl, Erik J., Rae Sajorda, Dannah, Berney-Meyer, Linda, Johnson, Samantha, Tufariello, JoAnn M., Fuhrer, Tobias, Cook, Gregory M., Jacobs, William R., Berney, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746716/
https://www.ncbi.nlm.nih.gov/pubmed/31527595
http://dx.doi.org/10.1038/s41467-019-12224-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746716/
https://www.ncbi.nlm.nih.gov/pubmed/31527595
http://dx.doi.org/10.1038/s41467-019-12224-3

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