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Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection
A major constraint for developing new anti-tuberculosis drugs is the limited number of validated targets that allow eradication of persistent infections. Here, we uncover a vulnerable component of Mycobacterium tuberculosis (Mtb) persistence metabolism, the aspartate pathway. Rapid death of threonin...
Autores principales: | Hasenoehrl, Erik J., Rae Sajorda, Dannah, Berney-Meyer, Linda, Johnson, Samantha, Tufariello, JoAnn M., Fuhrer, Tobias, Cook, Gregory M., Jacobs, William R., Berney, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746716/ https://www.ncbi.nlm.nih.gov/pubmed/31527595 http://dx.doi.org/10.1038/s41467-019-12224-3 |
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