TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain

The p53 homolog p63 plays important roles in development of epithelial tissues and quality control in germ cells. These two functions are executed by two distinct isoforms of p63. They are created by different promotors resulting in isoforms having either an N-terminal transactivation domain (TAp63)...

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Detalles Bibliográficos
Autores principales: Pitzius, Susanne, Osterburg, Christian, Gebel, Jakob, Tascher, Georg, Schäfer, Birgit, Zhou, Huiqing, Münch, Christian, Dötsch, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746776/
https://www.ncbi.nlm.nih.gov/pubmed/31527723
http://dx.doi.org/10.1038/s41419-019-1936-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746776/
https://www.ncbi.nlm.nih.gov/pubmed/31527723
http://dx.doi.org/10.1038/s41419-019-1936-z

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