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Anti-tumor activity of BET inhibitors in androgen-receptor-expressing triple-negative breast cancer

Triple-negative breast cancer (TNBC) is a heterogeneous disease comprising several subtypes. Androgen-receptor (AR) signaling has been targeted by several investigational agents in luminal AR subtype TNBCs. Bromodomain (BRD) and extra-terminal motif (BET) protein inhibitors have been shown to attenu...

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Detalles Bibliográficos
Autores principales: Park, In Hae, Yang, Han Na, Jeon, Su Yeon, Hwang, Jung-Ah, Kim, Min Kyeong, Kong, Sun-Young, Shim, Sung Hoon, Lee, Keun Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746817/
https://www.ncbi.nlm.nih.gov/pubmed/31527644
http://dx.doi.org/10.1038/s41598-019-49366-9