PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter

Protein kinase C (PKC)-interacting cousin of thioredoxin (PICOT; also termed glutaredoxin 3 (Grx3; Glrx3)) is a ubiquitous protein that can interact with the embryonic ectoderm development (EED) protein via each of its two C-terminal PICOT/Grx homology domains. Since EED is a Polycomb-Group protein...

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Detalles Bibliográficos
Autores principales: Pandya, Pinakin, Jethva, Minesh, Rubin, Eitan, Birnbaum, Ramon Y., Braiman, Alex, Isakov, Noah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746821/
https://www.ncbi.nlm.nih.gov/pubmed/31527584
http://dx.doi.org/10.1038/s41419-019-1935-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746821/
https://www.ncbi.nlm.nih.gov/pubmed/31527584
http://dx.doi.org/10.1038/s41419-019-1935-0

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